Investors

Corporate Background

Alpha Cancer Technologies Inc. (ACT) is a private clinical stage biotechnology company with platform technologies in Immunotherapy and Immuno-Oncology. These platforms under development treat auto-immune disease indications and cancer. The company’s drug products use our proprietary recombinant human alpha fetoprotein (AFP).

Immunotherapy the company is preparing to enter Phase II clinical trials in Inflammatory Bowel Disease (Crohn’s/Colitis) and is ready to enter Phase II clinical trials in Myasthenia Gravis (MG) (Orphan Drug Designation from FDA). ACT-101 (AFP) has been shown to be as safe as placebo in clinical trials in over 300 patients.

Immuno-Oncology AFP can deliver chemotherapy on a targeted basis to cancer cells and to suppressor cells which provides greater efficacy with significantly reduced toxicity.

Celgene is a 15% equity shareholder (August 2018) with no other commercial rights.

The company has a significantly mitigated risk profile in every area of development and an expedited clinical development path.

Game Changer

Immunotherapy

It is well-known that autoimmune diseases in women typically go into remission during pregnancy and there is a strong correlation between the level of AFP in mother’s blood and the decrease in the symptoms of her disease. In preclinical models of MG, AFP was able to block the MG antibodies from attacking the ACh receptors on the muscle.

Immuno-Oncology

In Oncology AFP is a carrier protein known for transporting nutrients to rapidly growing fetal cells and also acts as an immune regulatory protein involved in the protection of the fetus from attack by the mother’s immune system. Only trace amounts of the protein are found following the fetal stage but receptors for AFP show up again on almost all solid and liquid cancer cells. The company uses AFP to deliver a chemotherapy payload to selectively kill cancer cells and immune suppressor cells. Lower toxicity of this targeted approach offers the ability to treat the patient more frequently until the patient is cancer free.

Pipeline

ACT has several lead products that include non-covalently bound chemotherapy (paclitaxel, thapsigargin) and chemically linked chemotherapy such as maytansine. In addition to proven efficacy and known safety profile of generic chemotherapy drugs, AFP itself has been proven as safe as placebo in over 300 patients in Phase I and II clinical studies. ACT’s products are being developed as a treatment for multiple cancer indications as almost all cancer cells (>80%) express AFP receptors and healthy cells do not.

Therapy Indication Partners Discovery Pre-Clinical Phase I Phase II
ACT-101
(AFP)
Immunotherapy
Inflammatory Bowel Disease (Crohn’s/Colitis)
 
Myasthenia Gravis (muscle weakness)
 
Hashimoto Disease
 
Multiple Sclerosis, Others
 
ACT-901
(AFP + paclitaxel)
Targeted Immuno-Oncology
Solid and liquid tumors
Collaboration University Health Network
Princess Margaret Cancer Center
 
ACT-902
(AFP + thapsigargin)
Targeted Immuno-Oncology
Solid and liquid tumors
Collaboration University Health Network
 
ACT-903
(AFP + linker + maytansine)
Targeted Immuno-Oncology
Solid and liquid tumors
Collaboration Polytherics (Abzena) U.K.
 

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Alpha Cancer Technologies
www.alpha-cancer.com
200-101 College St.
Toronto, Ontario, M5G 1L7
Canada